All these are the twelve tribes of Israel. This is what their father said to them as he blessed them, blessing each with the blessing suitable to him.
One generation carries on after another. This is a recurring theme in Genesis where a repeating refrain is "these are the generations of...". This passage expands upon that theme with some specific blessings that Jacob gives to each of his sons, prophetically describing how each tribe will later come to function in the future nation of Israel.
From one couple, God populated the world. From human sins and choices, God has made Himself known, provided for access to Him, and graciously redeemed people to Himself. All of that is in Genesis. And it is told in the context of families. From Adam and Eve, to Noah and his sons, from Abraham and Sarai, on to Jacob and his sons. In all the story of human history told in the book, the clear denominator is family and home as relating to God and His grace and revelation.
So despite the vast cultural differences separating me from the patriarchs, I can identify with that common theme. I have a family and I relate to family. I am called to come to God in the context of my life and that includes family. And so I will trust and follow Him, while caring for the needs of those whom God has called me to love and need first -- family!